Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 12 Jon Cryer, Chris Kentis, Renee Olstead
- Season 12 Dennis Leary, Sam Easterson
- Season 12 Paul Hamm, Josh Hartnett, Nick Cave
- Season 12 Natalie Coughlin, Carla Gugino, Gavin DeGraw
- Season 12 Maureen Dowd, Tom Ryan
- Season 12 Carly Patterson, Jeff Foxworthy, LL Cool J
- Season 12 Farrah Fawcett, The Clarks
- Season 12 John McCain, Tom Russell
- Season 12 Tim Russert, Snow Patrol
- Season 12 Jane Pauley, Greg Giraldo
- Season 12 National Hollerin' Champions, Neve Campbell, Keane
- Season 12 Regis Philbin, Hoobastank
- Season 12 Martin Short, Alan Jackson
- Season 12 Ray Romano, Avril Lavigne
- Season 12 Drew Barrymore, Aron Ralston
- Season 12 John Kerry, Green Day
- Season 12 Dr. Phil, Gary Sinise
- Season 12 Kelly Ripa, Annie Duke, Elvis Costello
- Season 12 Stupid Human Tricks, Rob Lowe, Mos Def
- Season 12 Julianne Moore, Tom Dreesen
- Season 12 Queen Latifah, Jack Hanna
- Season 12 John Goodman, Tom Waits
- Season 12 Joaquin Phoenix, Austin Stevens, Switchfoot
- Season 12 John Travolta, Tim Frisby, Pearl Jam
- Season 12 Richard Gere, Jason Randal
- Season 12 Howard Dean, Franz Ferdinand
- Season 12 Annette Bening, Bill O'Reilly
- Season 12 Jamie Foxx, Davy Rothbart
- Season 12 Donald Trump, Brian Binnie, Minnie Driver
- Season 12 Brooke Shields, Barry Sonnenfeld
- Season 12 Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama
- Season 12 Laura Linney, Richard Lewis, The Wallflowers and Jordan Zevon
- Season 12 Jennifer Lopez, Sue Johanson
- Season 12 Billy Crystal, Ralph Nader
- Season 12 Tony Danza, Emma Roberts, Brian Regan
- Season 12 Jimmy Carter, Brandi Chastain, John Mellencamp
- Season 12 Jude Law, Ricky Gervais
- Season 12 Sarah Michelle Gellar, Tony Kanaan, Sparta
- Season 12 Dustin Hoffman, Joss Stone
- Season 12 Amy Sedaris, Tommy Lee
- Season 12 Johnny Damon, Anne Heche, The Donnas
- Season 12 Tom Brokaw, Mischa Barton
- Season 12 Rosie Perez, Steven Wright
- Season 12 Al Franken, Kristin Bell
- Season 12 Tom Hanks, Nelly
- Season 12 Salma Hayek, Sebastian Bourdais, Jimmy Eat World
- Season 12 Pierce Brosnan, Nigella Lawson, Renee Fleming
- Season 12 Matthew Broderick, Rosario Dawson, Los Lonely Boys
- Season 12 Paul Reubens, Evangeline Lilly, Project Bandaloop
- Season 12 Jerry Seinfeld, Jamie Oliver
- Season 12 Nicolas Cage, Jason Alexander, Morrissey
- Season 12 Renee Zellweger, Chris Raxworthy
- Season 12 Howard Stern, Alanis Morissette
- Season 12 Tom Brady, Damien Fahey
- Season 12 Stupid Pet Tricks, Colin Farrell, The Walkmen
- Season 12 Kevin Spacey, Ben Roethlisberger, Streb
- Season 12 Whoopi Goldberg, Jason Bateman, Marilyn Manson
- Season 12 Natalie Portman, John Mayer
- Season 12 Barack Obama, Jessica Biel
- Season 12 Matt Damon, Lance Armstrong
- Season 12 Alec Baldwin, Ken Jennings
- Season 12 Stupid Human Tricks, Noah Wylie, Sum 41
- Season 12 Sharon Reed, Tyra Banks, Lyle Lovett
- Season 12 Bonnie Hunt, Alex Zanardi
- Season 12 Jim Carrey, Ashanti
- Season 12 Cate Blanchett, Craig Ferguson, The Pixies
- Season 12 Adam Sandler, Sharon Ice
- Season 12 Kate Beckinsale, Ciara and Missy Elliot
- Season 12 Jeff Goldblum, Terrell Owens
- Season 12 Bill Murray, Kaki King
- Season 12 Dennis Quaid, Rusty Wallace, Kaki King
- Season 12 Kristin Johnson, Tom Dreesen
- Season 12 Regis Philbin, Jay Thomas, Darlene Love
- Season 12 Hilary Swank, Andy Dick, Green Day
- Season 12 Ethan Hawke, Maria Menounos, Alicia Keys
- Season 12 Kiefer Sutherland, Marv Albert, The Black Keys
- Season 12 Michael Keaton, Jamie Lynn Spears
- Season 12 Kevin Bacon, Caroline Rhea, Wilco
- Season 12 Samuel L. Jackson, Amy Poehler, B.B. King
- Season 12 Randy Johnson, Aisha Tyler, Razorlight
- Season 12 Rudolph Giuliani, Daniel Banks
- Season 12 Marge Helgenberger, Ryan Seacrest, My Chemical Romance
- Season 12 Amy Sedaris, Andy Kindler
- Season 12 Jack Hanna, Teri Polo
- Season 12 Ice Cube, Chris Russo, Interpol
- Season 12 Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead
- Season 12 Robert Downey Jr., Nicole Richie
- Season 12 Jerry Lewis, Sophia Bush
- Season 12 Peter Lassally, Doc Severinson
- Season 12 Debra Messing, Peyton Manning
- Season 12 Patricia Heaton, John Witherspoon, Gibson/Baldwin Grammy Jazz Ensembles
- Season 12 Elton John, Eva Mendes
- Season 12 Al Franken, Matthew Fox, Nanci Griffith
- Season 12 Will Smith, Tom Brady
- Season 12 Kevin James, Aishwarya Rai, Three Doors Down
- Season 12 David Hyde Pierce, Howie Day
- Season 12 Billy Crystal, Patrick Lawler
- Season 12 Paris Hilton, Bill Burr
- Season 12 Dr. Phil, Unwritten Law
- Season 12 Kid Scientists, Keanu Reeves, Michael Buble
- Season 12 Kelly Ripa, Taye Diggs
- Season 12 Charlie Sheen, Tori Amos
- Season 12 Roseanne Barr, Rachel Weisz
- Season 12 Stupid Pet Tricks, Bonnie Hunt
- Season 12 Barbara Walters, Rachel Bilson, Kings of Leon
- Season 12 Michael J. Fox, Amanda Bynes
- Season 12 John Travolta, Tony Kornheiser and Michael Wilbon
- Season 12 Ricky Gervais, Rachel Ray
- Season 12 The Rock, Solomon Burke
- Season 12 Kirstie Alley, Kathleen Edwards
- Season 12 Vin Diesel, Amos Lee
- Season 12 Dan Rather, Poppy Montgomery
- Season 12 Bruce Willis, Greg Giraldo
- Season 12 Ashton Kutcher, Al Green
- Season 12 Jimmy Fallon, Emily VanCamp, The Four Tops
- Season 12 Amanda Peet, Dean Kamazes
- Season 12 Sandra Bullock, Gwen Stefani
- Season 12 Jessica Alba, Brian Greene, Queens of the Stone Age
- Season 12 P. Diddy, Erika Christensen
- Season 12 Queen Latifah, Seth McFarlane
- Season 12 Britany Murphy, Bob Sarlatte, The John Butler Trio
- Season 12 Penelope Cruz, Sarah Vowell, Kaiser Chiefs
- Season 12 Denzel Washington, Faith Evans
- Season 12 Lisa Marie Presley, Ahmed Ibrahim, Jake Johannsen
- Season 12 Drew Barrymore, Charles Barkley
- Season 12 Show #2345
- Season 12 Show #2346
- Season 12 Mickey Rourke, Jason Randal
- Season 12 David Duchovny, Ray Lamontagne
- Season 12 Anthony LaPaglia, Ana Gasteyer, Mariah Carey
- Season 12 Kristin Chenowith, Johnny Lechner, Ludacris
- Season 12 Farrah Fawcett, Martin Freeman
- Season 12 Hank Azaria, Jeff MacGregor
- Season 12 Amy Sedaris, Daniel Tammet, LCD Soundsystem
- Season 12 Paris Hilton, Jo Frost
- Season 12 Teri Hatcher, Harry Hill
- Season 12 Martin Short, Elisha Cuthbert
- Season 12 Jennifer Lopez, Snoop Dogg
- Season 12 Orlando Bloom, Jack Hanna
- Season 12 Luke Wilson, Kasabian
- Season 12 Stupid Human Tricks, Christina Applegate, Brian Regan
- Season 12 Will Ferrell, Robert Plant
- Season 12 Helen Hunt, Tom Dreesen
- Season 12 Priscilla Presley, Quentin Tarantino
- Season 12 Billy Crystal, Garbage
- Season 12 Samuel L. Jackson, Sting
- Season 12 Ray Ramono, Dave Matthews Band
- Season 12 Ben Stiller, Sherry Fairchild
- Season 12 Chris Rock, Nicolette Sheridan
- Season 12 Ellen Degeneres, Hot Hot Heat
- Season 12 David Arquette, Gordon Ramsey
- Season 12 Paul Newman, Danica Patrick, Adam Savage & Jamie Hyneman
- Season 12 Adam Sandler, Reggie Miller, The Wallflowers
- Season 12 Kelly Ripa, Alexis Bledel, Ryan Adams & The Cardinals
- Season 12 Cedric the Entertainer, Dan Wheldon, The Black Eyed Peas
- Season 12 Russel Crowe, Paul Anka
- Season 12 Katie Holmes, The Shout Out Louds
- Season 12 Al Franken, Ellen Pompeo
- Season 12 Nicole Kidman, Foo Fighters
- Season 12 Show #2380
- Season 12 Show #2381
- Season 12 Show #2382
- Season 12 Show #2383
- Season 12 Show #2384
- Season 12 Show #2385
- Season 12 Show #2386
- Season 12 Show #2387
- Season 12 Show #2388
- Season 12 Show #2389
- Season 12 Julian McMahon/Raul Midon/Piedmont Bird Callers
- Season 12 Tom Brokaw/Dakota Fanning
- Season 12 Jennifer Connelly/Eels
- Season 12 Episode #12.174
- Season 12 Show #2394
- Season 12 Show #2395
- Season 12 Show #2396
- Season 12 Show #2397
- Season 12 Show #2398
- Season 12 John Cusack/The All-American Rejects
- Season 12 Show #2400
- Season 12 Kelly Preston/Jeff Altman/Aimee Mann
- Season 12 Bill Murray/Bettye LaVette
- Season 12 Show #2403
- Season 12 Lance Armstrong/Michael Ian Black
- Season 12 Show #2405
- Season 12 Show #2406
- Season 12 Show #2407
- Season 12 Show #2408
- Season 12 Show #2409
- Season 12 Show #2410
- Season 12 Show #2411
- Season 12 Show #2412
- Season 12 Show #2413
Late Show with David Letterman - Season 12 Episode 95 Kevin James, Aishwarya Rai, Three Doors Down
6.30 63 minutes Dave shows ""actual"" footage of the Hubble Telescope; Bollywood superstar Aishwarya Rai promotes Bride and Prejudice; 3 Doors Down performs ""Let Me Go.""
