Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 12 Jon Cryer, Chris Kentis, Renee Olstead
- Season 12 Dennis Leary, Sam Easterson
- Season 12 Paul Hamm, Josh Hartnett, Nick Cave
- Season 12 Natalie Coughlin, Carla Gugino, Gavin DeGraw
- Season 12 Maureen Dowd, Tom Ryan
- Season 12 Carly Patterson, Jeff Foxworthy, LL Cool J
- Season 12 Farrah Fawcett, The Clarks
- Season 12 John McCain, Tom Russell
- Season 12 Tim Russert, Snow Patrol
- Season 12 Jane Pauley, Greg Giraldo
- Season 12 National Hollerin' Champions, Neve Campbell, Keane
- Season 12 Regis Philbin, Hoobastank
- Season 12 Martin Short, Alan Jackson
- Season 12 Ray Romano, Avril Lavigne
- Season 12 Drew Barrymore, Aron Ralston
- Season 12 John Kerry, Green Day
- Season 12 Dr. Phil, Gary Sinise
- Season 12 Kelly Ripa, Annie Duke, Elvis Costello
- Season 12 Stupid Human Tricks, Rob Lowe, Mos Def
- Season 12 Julianne Moore, Tom Dreesen
- Season 12 Queen Latifah, Jack Hanna
- Season 12 John Goodman, Tom Waits
- Season 12 Joaquin Phoenix, Austin Stevens, Switchfoot
- Season 12 John Travolta, Tim Frisby, Pearl Jam
- Season 12 Richard Gere, Jason Randal
- Season 12 Howard Dean, Franz Ferdinand
- Season 12 Annette Bening, Bill O'Reilly
- Season 12 Jamie Foxx, Davy Rothbart
- Season 12 Donald Trump, Brian Binnie, Minnie Driver
- Season 12 Brooke Shields, Barry Sonnenfeld
- Season 12 Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama
- Season 12 Laura Linney, Richard Lewis, The Wallflowers and Jordan Zevon
- Season 12 Jennifer Lopez, Sue Johanson
- Season 12 Billy Crystal, Ralph Nader
- Season 12 Tony Danza, Emma Roberts, Brian Regan
- Season 12 Jimmy Carter, Brandi Chastain, John Mellencamp
- Season 12 Jude Law, Ricky Gervais
- Season 12 Sarah Michelle Gellar, Tony Kanaan, Sparta
- Season 12 Dustin Hoffman, Joss Stone
- Season 12 Amy Sedaris, Tommy Lee
- Season 12 Johnny Damon, Anne Heche, The Donnas
- Season 12 Tom Brokaw, Mischa Barton
- Season 12 Rosie Perez, Steven Wright
- Season 12 Al Franken, Kristin Bell
- Season 12 Tom Hanks, Nelly
- Season 12 Salma Hayek, Sebastian Bourdais, Jimmy Eat World
- Season 12 Pierce Brosnan, Nigella Lawson, Renee Fleming
- Season 12 Matthew Broderick, Rosario Dawson, Los Lonely Boys
- Season 12 Paul Reubens, Evangeline Lilly, Project Bandaloop
- Season 12 Jerry Seinfeld, Jamie Oliver
- Season 12 Nicolas Cage, Jason Alexander, Morrissey
- Season 12 Renee Zellweger, Chris Raxworthy
- Season 12 Howard Stern, Alanis Morissette
- Season 12 Tom Brady, Damien Fahey
- Season 12 Stupid Pet Tricks, Colin Farrell, The Walkmen
- Season 12 Kevin Spacey, Ben Roethlisberger, Streb
- Season 12 Whoopi Goldberg, Jason Bateman, Marilyn Manson
- Season 12 Natalie Portman, John Mayer
- Season 12 Barack Obama, Jessica Biel
- Season 12 Matt Damon, Lance Armstrong
- Season 12 Alec Baldwin, Ken Jennings
- Season 12 Stupid Human Tricks, Noah Wylie, Sum 41
- Season 12 Sharon Reed, Tyra Banks, Lyle Lovett
- Season 12 Bonnie Hunt, Alex Zanardi
- Season 12 Jim Carrey, Ashanti
- Season 12 Cate Blanchett, Craig Ferguson, The Pixies
- Season 12 Adam Sandler, Sharon Ice
- Season 12 Kate Beckinsale, Ciara and Missy Elliot
- Season 12 Jeff Goldblum, Terrell Owens
- Season 12 Bill Murray, Kaki King
- Season 12 Dennis Quaid, Rusty Wallace, Kaki King
- Season 12 Kristin Johnson, Tom Dreesen
- Season 12 Regis Philbin, Jay Thomas, Darlene Love
- Season 12 Hilary Swank, Andy Dick, Green Day
- Season 12 Ethan Hawke, Maria Menounos, Alicia Keys
- Season 12 Kiefer Sutherland, Marv Albert, The Black Keys
- Season 12 Michael Keaton, Jamie Lynn Spears
- Season 12 Kevin Bacon, Caroline Rhea, Wilco
- Season 12 Samuel L. Jackson, Amy Poehler, B.B. King
- Season 12 Randy Johnson, Aisha Tyler, Razorlight
- Season 12 Rudolph Giuliani, Daniel Banks
- Season 12 Marge Helgenberger, Ryan Seacrest, My Chemical Romance
- Season 12 Amy Sedaris, Andy Kindler
- Season 12 Jack Hanna, Teri Polo
- Season 12 Ice Cube, Chris Russo, Interpol
- Season 12 Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead
- Season 12 Robert Downey Jr., Nicole Richie
- Season 12 Jerry Lewis, Sophia Bush
- Season 12 Peter Lassally, Doc Severinson
- Season 12 Debra Messing, Peyton Manning
- Season 12 Patricia Heaton, John Witherspoon, Gibson/Baldwin Grammy Jazz Ensembles
- Season 12 Elton John, Eva Mendes
- Season 12 Al Franken, Matthew Fox, Nanci Griffith
- Season 12 Will Smith, Tom Brady
- Season 12 Kevin James, Aishwarya Rai, Three Doors Down
- Season 12 David Hyde Pierce, Howie Day
- Season 12 Billy Crystal, Patrick Lawler
- Season 12 Paris Hilton, Bill Burr
- Season 12 Dr. Phil, Unwritten Law
- Season 12 Kid Scientists, Keanu Reeves, Michael Buble
- Season 12 Kelly Ripa, Taye Diggs
- Season 12 Charlie Sheen, Tori Amos
- Season 12 Roseanne Barr, Rachel Weisz
- Season 12 Stupid Pet Tricks, Bonnie Hunt
- Season 12 Barbara Walters, Rachel Bilson, Kings of Leon
- Season 12 Michael J. Fox, Amanda Bynes
- Season 12 John Travolta, Tony Kornheiser and Michael Wilbon
- Season 12 Ricky Gervais, Rachel Ray
- Season 12 The Rock, Solomon Burke
- Season 12 Kirstie Alley, Kathleen Edwards
- Season 12 Vin Diesel, Amos Lee
- Season 12 Dan Rather, Poppy Montgomery
- Season 12 Bruce Willis, Greg Giraldo
- Season 12 Ashton Kutcher, Al Green
- Season 12 Jimmy Fallon, Emily VanCamp, The Four Tops
- Season 12 Amanda Peet, Dean Kamazes
- Season 12 Sandra Bullock, Gwen Stefani
- Season 12 Jessica Alba, Brian Greene, Queens of the Stone Age
- Season 12 P. Diddy, Erika Christensen
- Season 12 Queen Latifah, Seth McFarlane
- Season 12 Britany Murphy, Bob Sarlatte, The John Butler Trio
- Season 12 Penelope Cruz, Sarah Vowell, Kaiser Chiefs
- Season 12 Denzel Washington, Faith Evans
- Season 12 Lisa Marie Presley, Ahmed Ibrahim, Jake Johannsen
- Season 12 Drew Barrymore, Charles Barkley
- Season 12 Show #2345
- Season 12 Show #2346
- Season 12 Mickey Rourke, Jason Randal
- Season 12 David Duchovny, Ray Lamontagne
- Season 12 Anthony LaPaglia, Ana Gasteyer, Mariah Carey
- Season 12 Kristin Chenowith, Johnny Lechner, Ludacris
- Season 12 Farrah Fawcett, Martin Freeman
- Season 12 Hank Azaria, Jeff MacGregor
- Season 12 Amy Sedaris, Daniel Tammet, LCD Soundsystem
- Season 12 Paris Hilton, Jo Frost
- Season 12 Teri Hatcher, Harry Hill
- Season 12 Martin Short, Elisha Cuthbert
- Season 12 Jennifer Lopez, Snoop Dogg
- Season 12 Orlando Bloom, Jack Hanna
- Season 12 Luke Wilson, Kasabian
- Season 12 Stupid Human Tricks, Christina Applegate, Brian Regan
- Season 12 Will Ferrell, Robert Plant
- Season 12 Helen Hunt, Tom Dreesen
- Season 12 Priscilla Presley, Quentin Tarantino
- Season 12 Billy Crystal, Garbage
- Season 12 Samuel L. Jackson, Sting
- Season 12 Ray Ramono, Dave Matthews Band
- Season 12 Ben Stiller, Sherry Fairchild
- Season 12 Chris Rock, Nicolette Sheridan
- Season 12 Ellen Degeneres, Hot Hot Heat
- Season 12 David Arquette, Gordon Ramsey
- Season 12 Paul Newman, Danica Patrick, Adam Savage & Jamie Hyneman
- Season 12 Adam Sandler, Reggie Miller, The Wallflowers
- Season 12 Kelly Ripa, Alexis Bledel, Ryan Adams & The Cardinals
- Season 12 Cedric the Entertainer, Dan Wheldon, The Black Eyed Peas
- Season 12 Russel Crowe, Paul Anka
- Season 12 Katie Holmes, The Shout Out Louds
- Season 12 Al Franken, Ellen Pompeo
- Season 12 Nicole Kidman, Foo Fighters
- Season 12 Show #2380
- Season 12 Show #2381
- Season 12 Show #2382
- Season 12 Show #2383
- Season 12 Show #2384
- Season 12 Show #2385
- Season 12 Show #2386
- Season 12 Show #2387
- Season 12 Show #2388
- Season 12 Show #2389
- Season 12 Julian McMahon/Raul Midon/Piedmont Bird Callers
- Season 12 Tom Brokaw/Dakota Fanning
- Season 12 Jennifer Connelly/Eels
- Season 12 Episode #12.174
- Season 12 Show #2394
- Season 12 Show #2395
- Season 12 Show #2396
- Season 12 Show #2397
- Season 12 Show #2398
- Season 12 John Cusack/The All-American Rejects
- Season 12 Show #2400
- Season 12 Kelly Preston/Jeff Altman/Aimee Mann
- Season 12 Bill Murray/Bettye LaVette
- Season 12 Show #2403
- Season 12 Lance Armstrong/Michael Ian Black
- Season 12 Show #2405
- Season 12 Show #2406
- Season 12 Show #2407
- Season 12 Show #2408
- Season 12 Show #2409
- Season 12 Show #2410
- Season 12 Show #2411
- Season 12 Show #2412
- Season 12 Show #2413
Late Show with David Letterman - Season 12 Episode 116 Amanda Peet, Dean Kamazes
6.30 63 minutes Dave is able to work the phrase ""needlessly circuitous"" into the interview with Amanda Peet, plus he admires her profile; Alan gives suggestive advice to Condoleeza Rice; Susan Hum refuses to give her picks for the Final Four tournament; marathon man Dean Karnazes discusses the joy of running.
