Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 22 Luke Wilson, Julie Chen, Lee Brice
- Season 22 Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers
- Season 22 Steve Buscemi, Indy Car Season Champ, Alt-J
- Season 22 Tina Fey, Moody McCarthy, Kevin Drew
- Season 22 Bill Maher, Henrik Lundqvist, Spoon
- Season 22 Michael Strahan, Richard Branson, Interpol
- Season 22 Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson
- Season 22 Jason Bateman, Billy Eichner, Ryan Adams
- Season 22 Mindy Kaling, Jake Johannsen, Maddie & Tae
- Season 22 Mark Harmon, "Jungle" Jack Hanna
- Season 22 Denzel Washington, Lenny Kravitz
- Season 22 Kelly Ripa, Jim Gaffigan, Paloma Faith
- Season 22 Jerry Seinfeld, Michael Jackson ONE
- Season 22 Ted Danson, Andrew Norelli
- Season 22 Neil Patrick Harris, Jamie Oliver, Aretha Franklin
- Season 22 John Oliver, Maggie Q, Bleachers
- Season 22 Bill O'Reilly, Cristin Milioti
- Season 22 Johnny Galecki, Andre Benjamin, Delta Spirit
- Season 22 Mariska Hargitay, Simon Amstell, Kandace Springs
- Season 22 Aziz Ansari, Tom Dreesen
- Season 22 Robert Downey Jr., Sarah Paulson, Lizzo
- Season 22 Anderson Cooper, Gina Rodriguez, Hatsune Miku
- Season 22 Robert Duvall, Elle Fanning, Rival Sons
- Season 22 Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley
- Season 22 Russell Brand, Dave Grohl, Foo Fighters
- Season 22 Michael Keaton, Foo Fighters
- Season 22 Bill Murray, Foo Fighters
- Season 22 Tom Selleck, Jenny Slate, Foo Fighters
- Season 22 Jessica Chastain, Lenny Marcus, Foo Fighters
- Season 22 Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis
- Season 22 Taylor Swift, Tom Mison
- Season 22 Jim Carrey, David Tennant
- Season 22 Brian Williams, Perfume Genius
- Season 22 Keith Olbermann, Brian Regan, Run the Jewels
- Season 22 Martin Short, Father John Misty
- Season 22 Jennifer Lopez, Rob Riggle, Kimbra
- Season 22 Whoopi Goldberg, Jimmy Page, Mapei
- Season 22 Amy Schumer, Jeff Caldwell
- Season 22 Katie Holmes, Alex Zanardi
- Season 22 Steve Carell, Martha Stewart, OK Go
- Season 22 Jennifer Lawrence, Boris Johnson
- Season 22 Jon Stewart, Shawn Mendes
- Season 22 Kristin Chenoweth; Chris Young
- Season 22 Jason Sudeikis, Allison Janney, Damien Rice
- Season 22 Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger
- Season 22 Regis Philbin, Hundred Waters
- Season 22 Edward Norton, Jessye Norman
- Season 22 Norman Lear, TV on the Radio
- Season 22 Seth Rogen, Amy Sedaris
- Season 22 Emily Blunt, Adam Resnick, Wu-Tang Clan
- Season 22 Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz
- Season 22 Joaquin Phoenix, Cristela Alonzo, Al Green
- Season 22 Ben Stiller, Olivia Munn, LaLa Brooks
- Season 22 Meryl Streep, Rebel Wilson, J. Cole
- Season 22 Chris Rock, Sting
- Season 22 Jamie Foxx, Robert Klein, Dan Penn
- Season 22 Emma Stone Top, Marcus Mariota, Bob Seger
- Season 22 New Holiday Toys, Anna Kendrick, Charli XCX
- Season 22 Tom Brokaw, Will Nelson & Billy Joe Shaver
- Season 22 Rosie O’Donnel,l Jeff Altman
- Season 22 Jay Thomas, Josh Brolin, Darlene Love
- Season 22 Kathy Griffin, David Oyelowo, Lera Lynn
- Season 22 Ethan Hawke, Allison Williams, Parquet Courts
- Season 22 Julianne Moore, Catfish & the Bottlemen
- Season 22 Donald Trump, Chelsea Peretti, Foxygen
- Season 22 Michael Somerville, Nicole Atkins
- Season 22 Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones
- Season 22 Anderson Cooper, Shovels & Rope
- Season 22 Amanda Peet, Ryn Weaver
- Season 22 Larry David, Dan Patrick, Sleater-Kinney
- Season 22 Urban Meyer, Johnny Beehner, Ella Henderson
- Season 22 Louis CK, Nicolle Wallace, the Lone Bellow
- Season 22 Andrew Luck, Oscar Isaac, Drenge
- Season 22 Viola Davis, Ben Schwartz, Marty Stuart
- Season 22 John Oliver, Mayim Bialik, Death Cab for Cutie
- Season 22 Aziz Ansari, Brian Kiley, Ben Howard
- Season 22 Jack Hanna, Sharon Jones and the Dap-Kings
- Season 22 Dr. Phil McGraw, Robin Tunney, Diana Krall
- Season 22 Ryan Reynolds, Dierks Bentley
- Season 22 Martin Short, Bettye Lavette
- Season 22 Sienna Miller, Andy Kindler, Bob Mould
- Season 22 Steve Carell, Dr. Cornel West
- Season 22 Courtney Love, Chris Elliott, Rhiannon Giddens
- Season 22 Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear
- Season 22 Tom Hanks, Sturgill Simpson
- Season 22 Bill Hader, Pat McGann, Shakey Graves
- Season 22 Matthew Perry, Adam Scott, Kishi Bashi
- Season 22 Dakota Johnson, David Tochinskiy, Twin Shadow
- Season 22 Will Smith, Grizfolk
- Season 22 Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko
- Season 22 Kid Scientists, Sean Hayes, Judah & the Lion
- Season 22 Helen Mirren, the 2015 Daytona 500 winner, Steve Earle
- Season 22 Matthew Broderick, Ellie Kemper, JD McPherson
- Season 22 Julianna Margulies, Eric Ripert, Glass Animals
- Season 22 Kevin Spacey, Lily James, Alabama Shakes
- Season 22 Patricia Arquette, Will Butler
- Season 22 Kelsey Grammer, Stevie Wonder
- Season 22 Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew
- Season 22 Kevin Bacon, Jimmie Walker, Airborne Toxic Event
- Season 22 Shailene Woodley, Dr. Cornel West, Matthew E. White
- Season 22 Will Ferrell, Glen Hansard
- Season 22 Norm MacDonald, Theo James
- Season 22 Ben Stiller, Tove Lo
- Season 22 Bill O'Reilly, Aubrey Plaza
- Season 22 James Franco, Jake Johannsen, Action Bronson
- Season 22 Neil Patrick Harris, Charlie Cox, the Suffers
- Season 22 David Duchovny, Josh Gad, Houndmouth
- Season 22 Sen. Al Franken, Billy Eichner, David Sanborn
- Season 22 Kelly Ripa, Aasif Mandvi, Fat White Family
- Season 22 Mike Myers, Nick Griffin, Banks
- Season 22 Sarah Jessica Parker, Julie Chen, Asleep at the Wheel
- Season 22 Billy Crystal, Chris Russo, Chris Stapleton
- Season 22 Michael J. Fox, Iron & Wine, Ben Bridwell
- Season 22 Kevin James, Tom Dreesen, Tracy Chapman
- Season 22 Alec Baldwin, John Mayer
- Season 22 John Travolta, Amy Schumer, the Waterboys
- Season 22 Piedmont Bird Callers, Paul Rudd
- Season 22 Bruce Willis, Dawes
- Season 22 Robert Downey Jr., Chris Russo, Elvis Costello
- Season 22 Jerry Seinfeld, Jason Isbell & Amanda Shires
- Season 22 Scarlett Johansson, John Mellencamp, Todd Rundgren
- Season 22 Michael Keaton, Future Islands
- Season 22 Jack Hanna, John Popper
- Season 22 First Lady Michelle Obama Hootie and the Blowfish
- Season 22 Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor
- Season 22 President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile
- Season 22 Reese Witherspoon, Nathan Lane, Mumford & Sons
- Season 22 Martin Short, Norah Jones
- Season 22 Tina Fey, First Aid Kit
- Season 22 Ray Romano, Brian Regan, Dave Matthews Band
- Season 22 Howard Stern, Don Rickles
- Season 22 Bill Clinton, Adam Sandler
- Season 22 Julia Roberts, Paul Shaffer, Ryan Adams
- Season 22 Al Pacino, George Clooney, Tom Waits
- Season 22 Oprah Winfrey, Norm Macdonald
- Season 22 Tom Hanks, Eddie Vedder
- Season 22 Bill Murray, Bob Dylan
- Season 22 The Final Late Show with David Letterman
- Season 22 Episode 149
Late Show with David Letterman - Season 22 Episode 61 Jay Thomas, Josh Brolin, Darlene Love
6.33 63 minutes The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).
