Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 15 Former President Bill Clinton, Patti Scialfa
- Season 15 Danny DeVito, Larry David, Avril Lavigne
- Season 15 Jessica Alba, George Saunders, The Manchester Orchestra
- Season 15 Rachael Ray, Frank Rich, Arctic Monkeys
- Season 15 Jodie Foster, Glen Hansard & Markéta Irglová
- Season 15 Dr. Phil McGraw, Andy Kindler, Suzanne Vega
- Season 15 Viggo Mortensen, Kat Von D, Daughtry, a Top Ten List presented by 10 NASCAR stars
- Season 15 Martha Stewart, Fred Willard, a Top Ten List presented by Billy Bob Thornton
- Season 15 Regis Philbin, Chamillionaire
- Season 15 Jamie Foxx, Jimmy Smits, Will.I.Am
- Season 15 Kate Walsh, Kevin Smith, Rascal Flatts
- Season 15 Jennifer Garner, Ken Burns, Chaka Khan
- Season 15 Stupid Human Tricks, Whoopi Goldberg, Melissa Etheridge
- Season 15 Paris Hilton, Emile Hirsch
- Season 15 Sean Penn, Barry Sonnenfeld, Ben Harper
- Season 15 Jude Law, Sarah Silverman, John Fogerty
- Season 15 Alec Baldwin, Faith Hill
- Season 15 Nicolette Sheridan, Tony Snow, Rihanna
- Season 15 Bob Newhart, Angela Kinsey, Iron and Wine
- Season 15 George Clooney, Kid Rock
- Season 15 Jennifer Lopez, Alan Greenspan
- Season 15 Stephen Colbert, Eva Mendes, Queens of the Stone Age
- Season 15 Anne Heche, Sue Johanson, Mariza
- Season 15 Halle Berry, Bill Hader, Spring Snake Symphony
- Season 15 Jake Gyllenhaal, Connie Britton, 50 Cent
- Season 15 Richard Simmons, Casey Affleck, Sondre Lerche
- Season 15 Rebecca Romijn, Jimmie Walker, LeAnn Rimes
- Season 15 Steve Carell, Chris Russo, Chris Elliott, Band of Horses
- Season 15 Amanda Peet, Patrick Warburton, Jeff Caldwell
- Season 15 Jerry Seinfeld, Joe Torre
- Season 15 Jennifer Connelly, Slash, Nicole Atkins
- Season 15 David Spade, Penn & Teller, Jonathan Papelbon
- Season 15 Dr. Phil McGraw, Ryan Adams
- Season 15 Bill Murray, Jay-Z
- Season 15 Robin Williams, Lupe Fiasco
- Season 15 Bill Maher, Ellen Page, the cast of Broadway's "Young Frankenstein"
- Season 15 Donald Trump, Shooter Jennings
- Season 15 Tom Hanks, Gov. Mike Huckabee
- Season 15 Lucy Liu, Alex Roy, MGMT
- Season 15 Morgan Freeman, Tom Brokaw, Chuck Prophet
- Season 15 Howard Stern, Ayo
- Season 15 Tracy Morgan, Kat Von D, Dropkick Murphys
- Season 15 Katie Holmes, Frank Caliendo, Maroon 5
- Season 15 Denzel Washington, Don Rickles
- Season 15 Michael Douglas, Katherine Heigl, Wyclef Jean
- Season 15 Sylvester Stallone, the Teutul family, the Mars Volta
- Season 15 Diane Keaton, Jim Gaffigan
- Season 15 Sarah Michelle Gellar, Dan Patrick, Ringo Starr
- Season 15 Sen. John Edwards, Diablo Cody, Josh Ritter, David "Fathead" Newman
- Season 15 Charles Grodin, New York Giant Lawrence Tynes, The Redwalls
- Season 15 Julia Louis-Dreyfus, T.J. Miller, Super Furry Animals
- Season 15 Nathan Lane, Jake Johannsen
- Season 15 Jessica Alba, Julie Chen, The Whigs
- Season 15 Bill Cosby, Lake Bell, The Matt Savage Trio
- Season 15 Dr. Phil McGraw, Lena Headey, Gary Allan
- Season 15 Stupid Human Tricks, Eva Longoria Parker, Colbie Caillat
- Season 15 Paris Hilton, Artie Lange, Vampire Weekend
- Season 15 Sen. Hillary Clinton, Sheryl Crow
- Season 15 Matthew McConaughey, Gary Mule Deer, Sheryl Crow
- Season 15 Eli Manning, Vince Vaughn, A Fine Frenzy
- Season 15 Kate Hudson, Jack Hanna
- Season 15 Colin Farrell, Blake Lively, Lenny Kravitz
- Season 15 Kate Walsh, Jason Sudeikis, OK Go and Bonerama
- Season 15 Evangeline Lilly, Marisa Miller, Brad Paisley
- Season 15 Martin Short, Amy Ryan
- Season 15 Regis Philbin, Joseph Arthur
- Season 15 Charles Barkley, Bill Burr
- Season 15 Dennis Quaid, Ryan Newman, Sharon Jones and the Dap-Kings
- Season 15 Randy Jackson, Saffron Burrows, Ray Davies
- Season 15 Amy Sedaris, Erika Jensen, Foo Fighters
- Season 15 Steve Martin, hand shadows performance with Raymond Crowe
- Season 15 Diddy, Al Lubel
- Season 15 Will Ferrell, Michael McDonald
- Season 15 Courteney Cox, Thomas Friedman, Chingy with Ludacris
- Season 15 Kid Scientists, Natalie Portman, Kenna
- Season 15 Amy Adams, Jamie Oliver, Liam Finn
- Season 15 Woody Harrelson, Tommy Tiernan
- Season 15 Jim Carrey, Paula Abdul
- Season 15 Martha Stewart, Snoop Dogg
- Season 15 Charlize Theron, Lewis Black, British Sea Power
- Season 15 Kate Beckinsale, Graham Colton
- Season 15 Jaime Pressly, Brian Regan
- Season 15 Rainn Wilson, Mike Golic & Mike Greenberg, Bell X1
- Season 15 Al Franken, Lauren Conrad, The Cribs
- Season 15 Brooke Shields, Seth Meyers, Gutter Twins
- Season 15 Demi Moore, Anthony Bourdain, Counting Crows
- Season 15 Kate Bosworth, John Witherspoon, The Raveonettes
- Season 15 Brian Williams, Judy Greer, Langhorne Slim
- Season 15 Helen Mirren, Jose Canseco
- Season 15 Sen. John McCain, Cat Power
- Season 15 George Clooney, Norah Jones
- Season 15 Renee Zellweger, Gayle King, Paddy Casey
- Season 15 Ellen Pompeo, Jay-Z, Mary J. Blige
- Season 15 Al Pacino, David Wright
- Season 15 Kelsey Grammer, Kristen Bell, Rogue Wave
- Season 15 Uma Thurman, Graham Rahal, The Gossip
- Season 15 Kelly Ripa, Dr. John P. Holdren, The Black Keys
- Season 15 Amy Poehler, Jason Segel, Jordan Zevon
- Season 15 Billy Crystal, Maria Sharapova
- Season 15 Helen Hunt, Chris "Mad Dog" Russo, Kathleen Edwards
- Season 15 Danica Patrick, Russell Brand, Tokyo Police Club
- Season 15 Tina Fey, Brett Favre, Estelle
- Season 15 Craig Ferguson, Ira Glass, The Black Crowes
- Season 15 Gwyneth Paltrow, Richard Lewis, The Roots with Chrisette Michele
- Season 15 Robert Downey Jr., Alicia Keys
- Season 15 Matthew Broderick, Heidi Montag, Josh Groban
- Season 15 John Goodman, Bear Grylls, Robyn
- Season 15 Patrick Dempsey, Isabella Rossellini, Nick Lowe
- Season 15 Jimmy Kimmel, Lance Burton, Jimmy Eat World
- Season 15 Ashton Kutcher, Mac King, Steve Winwood
- Season 15 Emile Hirsch, Tom Dreesen, Dirk Arthur
- Season 15 Paris Hilton, Steve Wyrick, Panic at the Disco
- Season 15 Barbara Walters, Cobie Smulders, Penn & Teller
- Season 15 Stupid Pet Tricks, Shia LaBeouf, N.E.R.D.
- Season 15 Regis Philbin, Laura Dern, Death Cab for Cutie
- Season 15 Jack Hanna, Kid Rock
- Season 15 America Ferrera, Russell Brand, Terry Fator
- Season 15 Teri Hatcher, Robert F. Kennedy Jr.
- Season 15 Kevin Spacey, Sen. Jim Webb, Sara Bareilles
- Season 15 Harrison Ford, Ali Lohan, Leona Lewis
- Season 15 Kristin Davis, Jimmy Buffett
- Season 15 Sarah Jessica Parker, Piedmont Bird Callers, Republic Tigers
- Season 15 Liv Tyler, Sue Johanson, Tommy Johnagin
- Season 15 Adam Sandler, Scott Dixon, Donna Summer
- Season 15 Julianne Moore, Morgan Spurlock, a performance from the Broadway musical "South Pacific"
- Season 15 Jack Black, Esperanza Spalding
- Season 15 Julia Roberts, Al Green
- Season 15 Jenna Fischer, Jim Nantz, Gavin Rossdale
- Season 15 Tom Brokaw, Elettra Wiedemann, Gnarls Barkley
- Season 15 Mark Wahlberg, Jeff Peckman, Alanis Morissette
- Season 15 Zooey Deschanel, Scott McClellan, Jakob Dylan
- Season 15 Ben Kingsley, Artie Lange, Emmylou Harris
- Season 15 Whoopi Goldberg , Spencer Pratt, Nick Griffin
- Season 15 Mike Myers, BMX star Kevin Robinson, Adele
- Season 15 Steve Carell, Lance Armstrong, Dr. John
- Season 15 Kevin Garnett & Ray Allen, Jane Krakowski, Martha Wainwright
- Season 15 Jason Bateman, Teri Garr, Keyshia Cole
- Season 15 Denis Leary, The Baseball Project
- Season 15 Will Smith, Joe Buck
- Season 15 Charlize Theron, Richard Belzer, Mötley Crüe
- Season 15 Abigail Breslin, Barry Sonnenfeld, Tift Merritt
- Season 15 Mary-Kate Olsen, Jim Gaffigan, Gavin DeGraw
- Season 15 Morgan Freeman, Kaley Cuoco, Wild Sweet Orange
- Season 15 Pierce Brosnan, Bud Selig, Jason Mraz
- Season 15 Meryl Streep, Aaron Eckhart, Randy Travis
- Season 15 Maggie Gyllenhaal, Neil Young, The Hold Steady
- Season 15 Ricky Gervais, John Mellencamp
- Season 15 Rosie Perez, David Sedaris
- Season 15 Will Ferrell, Adam Savage & Jamie Hyneman
- Season 15 Amanda Peet, Jon Hamm, Augustana
- Season 15 John C. Reilly, Jane Mayer, Grizzly Bear
- Season 15 David Duchovny, Black Kids
- Season 15 Nathan Lane, Larry "Bubbles" Brown, Randy Bachman
- Season 15 Gillian Anderson, Simon Pegg, We Are Scientists
- Season 15 Kevin Costner, Bob Sarlatte, Low vs. Diamond
- Season 15 Pamela Anderson, James Franco, Atmosphere
- Season 15 Luke Wilson, Mindy Kaling, Michael Lauziere
- Season 15 Richard Simmons, Mary-Louise Parker
- Season 15 Seth Rogen, Fleet Foxes
- Season 15 Kelly Ripa, Steve Coogan, Spiritualized
- Season 15 Penelope Cruz, Danny Way, Randy Newman
- Season 15 Kiefer Sutherland, Rumer Willis, Phil Vassar
- Season 15 Donald Trump, Dwayne Kennedy
- Season 15 Shawn Johnson, Tracy Morgan, Solange
- Season 15 Bryan Clay, Don Cheadle, Little Anthony & The Imperials
- Season 15 Kerri Walsh & Misty May-Treanor, Neil Patrick Harris, Nas
- Season 15 Brad Garrett, Blake Lively, Randy Houser
- Season 15 Amy Sedaris, Kim Kardashian, Brian Regan
Late Show with David Letterman - Season 15 Episode 86 Demi Moore, Anthony Bourdain, Counting Crows
6.33 63 minutes An audience woman shares her own tick bite experience with Dave; Alan narrates a history of the Ed Sullivan Theater, then cuts himself off to use the washroom; Demi Moore discusses leach therapy and plugs Flawless; Counting Crows perform "You Can't Count On Me."
