Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 10 Amanda Peet, Tom Dreesen
- Season 10 Jeff Goldblum, George Miller
- Season 10 Drea de Matteo, Sarah Vowell, The Doves
- Season 10 Peter Jennings, John Witherspoon
- Season 10 John McEnroe, Piper Perabo, Queens of the Stone Age
- Season 10 Jennifer Esposito, Marianne Faithful
- Season 10 Bill Clinton, Nanci Griffith
- Season 10 Regis Philbin, Linda Thompson
- Season 10 Megan Mullally, Rich Hall
- Season 10 Bruce Willis, Eve
- Season 10 Jack Hanna, Tom Cavanagh, Civil War Reenactment
- Season 10 Reese Witherspoon, Juan Montoya, India.Arie
- Season 10 Rose McGowan, Phillipe Petit
- Season 10 Lauren Graham, Colin Quinn
- Season 10 Patricia Heaton, Murray Walker
- Season 10 David Schwimmer, Avril Lavigne
- Season 10 Anthony LaPaglia, Effie Nielson, Clinic
- Season 10 Edward Norton, John Mayer
- Season 10 David Arquette, Todd Lynn
- Season 10 Jennifer Love Hewitt, Tom Petty and The Heartbreakers
- Season 10 John McCain, David Sedaris
- Season 10 Charles Barkley, Franco Zeffirelli, Nitty Gritty Dirt Band
- Season 10 Michelle Pfeiffer, Bon Jovi
- Season 10 Johnny Knoxville, Ron White
- Season 10 Debra Messing, Pink
- Season 10 Thandie Newton, Faith Hill
- Season 10 Rudolph Giuliani, Naomi Watts
- Season 10 Samuel L. Jackson, Santana & Michelle Branch
- Season 10 P. Diddy, Eddie Brill
- Season 10 Bonnie Hunt, Christina Aquilera
- Season 10 Salma Hayek, Tori Amos
- Season 10 Warren Zevon
- Season 10 Jerry Seinfeld, Foo Fighters
- Season 10 Don Rickles, Jim Gaffigan
- Season 10 Stupid Human Tricks, Sean Hayes, Willie Nelson & Ryan Adams
- Season 10 Julianne Moore, Grant Paulsen, Blind Boys of Alabama
- Season 10 Kid Inventors, Tom Brokaw, The Wallflowers
- Season 10 Brittany Murphy, Al Lubel
- Season 10 Robin Williams, Emily Proctor
- Season 10 Kelly Ripa, Emmitt Smith, Missy Elliott
- Season 10 Barbara Walters, Joe Pantoliano
- Season 10 Maggie Gyllenhaal, Pearl Jam
- Season 10 Al Gore, Pearl Jam
- Season 10 Kevin James, matchbox 20
- Season 10 Shania Twain, Cristiano da Matta
- Season 10 Adam Sandler, Pussycat Dolls
- Season 10 Ice Cube, Cast of Hairspray
- Season 10 Harry Connick Jr., Larry Miller
- Season 10 Stupid Pet Tricks, Lisa Kudrow, Audioslave
- Season 10 George Clooney, Jack Hanna
- Season 10 Ray Romano, Jurassic 5
- Season 10 Amy Sedaris, The Strokes
- Season 10 Liza Minnelli, Jann Karam
- Season 10 Jennifer Lopez, Sum 41
- Season 10 Jason Alexander, Ryan Adams
- Season 10 Nia Vardalos, Barry Sonnenfeld
- Season 10 Allison Janney, Martin Scorsese
- Season 10 Natasha Richardson, Mike Birbiglia, David Gray
- Season 10 Catherine Zeta-Jones, Coldplay
- Season 10 Drew Barrymore, Rod Stewart
- Season 10 Denzel Washington, Daniel Bouloud
- Season 10 Tom Hanks, Phish
- Season 10 Liv Tyler, Jay Thomas, Darlene Love
- Season 10 Ashton Kutcher, Jason Kidd
- Season 10 Isabella Rossellini, Mort Sahl
- Season 10 Michael Caine, George Foreman
- Season 10 Richard Gere, Chris Elliott
- Season 10 Merv Griffin, Interpol
- Season 10 Renee Zellweger, Chuck Barris
- Season 10 Andy Richter, Rich Hall
- Season 10 Jimmy Kimmel, Simon Baker
- Season 10 Claire Danes, Bob Sarlatte
- Season 10 Sandra Bullock, Marv Albert
- Season 10 George Clooney, Soundtrack of Our Lives
- Season 10 Joan Rivers, Kathleen Edwards
- Season 10 Simon Cowell, Topher Grace, Vienna Teng
- Season 10 Regis Philbin, John C. Reilly
- Season 10 Tina Fey, Jonathan Ames, Johnny Marr & The Healers
- Season 10 Ellen DeGeneres, Zwan
- Season 10 Bonnie Hunt, John Witherspoon
- Season 10 Show #1944Kate Hudson, Jack Hanna
- Season 10 Matthew McConaughey, John Gruden, The Roots
- Season 10 Kelsey Grammer, Michael Tong, B.B. King and Shemeika Copeland
- Season 10 Stupid Pet Tricks, Tom Brokaw, The Pretenders
- Season 10 Brendan Fraser, Kids in The Hall, Bonnie Raitt, Keb' Mo, Kim Wilson
- Season 10 Matthew Broderick, Tony Bennett & k.d. Lang
- Season 10 Amy Brennamen, Nate Erwin, Vince Gill
- Season 10 Queen Latifah, Colin Quinn, Lou Reed
- Season 10 Kid Scientists, Kurt Russell
- Season 10 Kate Winslet, Dennis Regan, Rufus Wainwright
- Season 10 Dr. Phil, Beck
- Season 10 Vince Vaughn, Sarah Vowel, Beck
- Season 10 Kevin Spacey, Reggie Miller
- Season 10 Champion Turkey Callers, Marg Helgenberger, The Flaming Lips
- Season 10 Jeff Daniels, Lynne Cox, Steven Wright
- Season 10 Steve Martin, Foo Fighters
- Season 10 Stupid Human Tricks, Sharon Osborne, Norah Jones
- Season 10 Bruce Willis, Dan Rather, Carmen Electra, Brian Kiley
- Season 10 John McEnroe, Tom Arnold, Eric Ripert, Todd Barry, Jason Mras
- Season 10 Regis Philbin, Charles Grodin, Susan Lucci, Greg Giraldo, Kathleen Edwards
- Season 10 Whoopi Goldberg, Jessica Lange, Dave Chappelle, Andy Vistola, Ben Harper
- Season 10 Vince Vaughn, Rosie Perez, Geri Halliwell, Dwayne Kennedy, Paul Simon
- Season 10 Elvis Costello, Kim Cattrell, Eddie Izzard, Mitch Hedberg
- Season 10 Will Ferrell, Chris Rock, Crispin Glover, Jake Johannsen, American Hi-Fi
- Season 10 Megan Mullally, Molly Shannon, Isaac Mizrahi, Bonnie McFarlane
- Season 10 Brad Garrett, Cuba Gooding Jr., Julie Bowen, Reggie McFadden, Lyle Lovett
- Season 10 Tom Dreesen, Kiefer Sutherland, Frank Gershin, Suzanne Westenhoefer, The Music
- Season 10 Bonnie Hunt, Carson Daley, Eddie Griffin, Ron Beth-Israel, Fabolous
- Season 10 Paul Schaffer, Bob Dole, Connie Nielsen, Jeff Foxworthy, Cat Power
- Season 10 Bill Cosby, Andrew Firestone, Clark Tery, Sofia Vergara, The DA
- Season 10 Luke Wilson, Kelly Preston, Taye Diggs, Hilary Burton, Seether
- Season 10 Billy Crystal, Michael Barimo
- Season 10 Colin Farrell, Rosanne Cash
- Season 10 Helen Hunt, Jeremy Suarez, Cory Branan
- Season 10 High-Jumping Dogs, Vin Diesel, Bo Diddley
- Season 10 Hilary Swank, Jimmie Walker
- Season 10 Adam Sandler, The Folksmen
- Season 10 Lisa Marie Presley, Jamie Kennedy
- Season 10 Jane Krakowski, Jim Boeheim, Pete Yorn
- Season 10 Tom Brokaw, Tom Russell & Nanci Griffith
- Season 10 Michael Douglas, Todd Rundgren
- Season 10 Anthony LaPaglia, Brian Regan, The Exies
- Season 10 Ashton Kutcher, Jack Hanna
- Season 10 Ellen DeGeneres, John Malkovich
- Season 10 Charlize Theron, Sue Johanson, Minus 5 with Wilco
- Season 10 Bernie Mac, Amanda Peet
- Season 10 Halle Berry, Don Rickles
- Season 10 Kelly Rippa, Good Charlotte
- Season 10 Stupid Human Tricks, Hugh Jackson, Kelly Clarkson
- Season 10 David Hyde Pierce, Rube Goldberg Contest Winners, Ziggy Marley
- Season 10 Megan Mullally, Marilyn Manson
- Season 10 Albert Brooks, Jeffery Ross, The Libertines
- Season 10 Stupid Pet Tricks, Kevin James, Jenna Morasca
- Season 10 David Williams & Ronald Young, Jada Pinkett Smith, The Jayhawks
- Season 10 Sean Hayes, Eric Ripert, Avril Lavigne
- Season 10 Rene Zellweger, Jack Johnson
- Season 10 John Goodman, D.H. Hughley, NAS with Alicia Keys
- Season 10 Mark Wahlberg, Jesse James, the Sounds
- Season 10 Jim Carrey, Chevelle
- Season 10 Regis Philbin, 3 Doors Down
- Season 10 Antonio Banderas, Heidi Klum, Liam Lynch
- Season 10 Peter Krause, Jim Gaffigan, Widespread Panic
- Season 10 Adrien Brody, Gil de Ferran, John Mellencamp
- Season 10 Alec Baldwin, Tom Dreesen
- Season 10 Seth Green, Amy Sedaris, Lucinda Williams
- Season 10 Barbara Walters, Tanya Streeter
- Season 10 Tom Arnold, Darrell Hammond, Karolina Kurkova, Eddie Brill, Train
- Season 10 Juliette Binoche, Joe Queenan, Blur
- Season 10 Bruce Willis, Chris Moneymaker
- Season 10 Lauren Graham, Marv Albert, Bright Eyes
- Season 10 Harrison Ford, Annie Lennox
- Season 10 Tom Green, Jolene Blalock, Scott Stevens, Isaac Britty, Damien Rice
- Season 10 Hilary Clinton, Emmylou Harris
- Season 10 Rob Reiner, Paul Teutul Sr. & Jr., The New Pornographers
- Season 10 Johnny Depp, Christine Todd Whitman, B.B. King
- Season 10 Sarah Jessica Parker, The Dead
- Season 10 Kelsey Grammer, Treat Williams, James Earl Jones, Jamie Lynn-Sigler, Kathleen Madigan, Jesse Malin
- Season 10 Demi Moore, Verbana
- Season 10 Drew Barrymore, Simon Cowell
- Season 10 Lucy Liu, Avigayil Wardein, Nick Cave and The Bad Seeds
- Season 10 Piedmont Bird Callers, Luke Wilson, The Yeah Yeah Yeahs
- Season 10 Jimmy Fallon, Kristanna Loken, Dax, Chloe Sevigny, Bill Scheft, Rufus Wainwright
- Season 10 Lisa Marie Presley, Ryan Pinkston
- Season 10 Allison Janney, Nigella Lawson, Howard Tate
- Season 10 Barry Zito, Mandy Moore, Grandaddy
- Season 10 Ari Fleischer, Beyonce Knowles
- Season 10 Jeff Bridges, Alan Harvey, Joseph Arthur
- Season 10 Aron Ralston, Tobey Maguire
- Season 10 National Hollerin' Champions, Kristin Davis, Jane's Addiction
- Season 10 Joaquin Phoenix, Blues Traveler
- Season 10 Sylvester Stallone, Ben Curtis
- Season 10 Denis Leary, Queens of the Stone Age
- Season 10 Jesse Grabow, Jason Biggs, Robert C. Nichol
- Season 10 Eugene Levy, Eels
- Season 10 Seann William Scott, Jonathan Ames, Fountains of Wayne
- Season 10 Melanie Griffith, Pamela Reed
- Season 10 Naomi Watts, Jeff Stilson, O.A.R.
- Season 10 Kate Hudson, Cast of Camp
- Season 10 Colin Farrell, Robert Randolph & The Family Band
- Season 10 Samuel L. Jackson, Rick Reilly, Pharrell with Clipse
- Season 10 Brittany Murphy, Carey Hart, Dashboard Confessional
- Season 10 David Duchovny, Brett Butler, The New Amsterdams
- Season 10 Chris Rock, The Star Spangles
- Season 10 Bill Murray, Pete Sampras
- Season 10 David Spade, Bob Sarlatte, Maroon 5
- Season 10 Tony Hawk, John McEnroe, Rooney
- Season 10 Bonnie Hunt, Don Gavin
Late Show with David Letterman - Season 10 Episode 107 Tom Dreesen, Kiefer Sutherland, Frank Gershin, Suzanne Westenhoefer, The Music
6.33 63 minutes Chicago-born comedian (and old friend of Dave's) Tom Dreseen becomes the latest fill-in host for Dave. He mentions that a fan outside the theater mistook him for Regis, then goes a spiel about his daughter's love of hip-hop. Also, lesbian comedian Suzanne Westenhoefer performs.
