Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 16 Nicolas Cage, Anna Torv, Terrence Howard
- Season 16 Dr. Phil McGraw, Tilda Swinton, Tricky
- Season 16 Robin Williams, Shannen Doherty, Duffy
- Season 16 John Malkovich, Hayden Panettiere, Steve Earle
- Season 16 Keira Knightley, Thomas L. Friedman
- Season 16 Jada Pinkett Smith, Chris Russo, Michael Buble
- Season 16 Sen. Barack Obama, LeBron James
- Season 16 Jessica Simpson, Jack Hanna
- Season 16 Meg Ryan, Ricky Gervais
- Season 16 Bill Clinton, Chris Rock
- Season 16 Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon
- Season 16 Keith Olbermann, Chandra Wilson, Delta Goodrem
- Season 16 Paris Hilton, Usain Bolt, Morningwood
- Season 16 Lance Armstrong, Kristen Wiig, TV on the Radio
- Season 16 Julia Louis-Dreyfus, Michael Cera, Pete Seeger
- Season 16 Anne Hathaway, Josette Sheeran, The Virgins
- Season 16 Kate Walsh, Barry Sonnenfeld, Darius Rucker
- Season 16 Calista Flockhart, Bill Hader, Lucinda Williams
- Season 16 Brian Williams, Tim Robbins
- Season 16 Russell Crowe, Sarah Vowell, The Pretenders
- Season 16 Debra Messing, John Carter, Tegan & Sara
- Season 16 Dennis Quaid, Sarah Chalke, Buddy Guy
- Season 16 Bill Murray, Beck
- Season 16 Jeremy Piven, Elizabeth Banks, Lou Reed
- Season 16 Sarah Silverman, the Teutuls, Ra Ra Riot
- Season 16 Josh Brolin, Amy Sedaris, Blues Traveler
- Season 16 Martin Short, Marv Albert
- Season 16 Sen. John McCain, Ne-Yo
- Season 16 Tina Fey, Frank Caliendo, Tim Montana
- Season 16 Bill O'Reilly, Lauren Conrad
- Season 16 Regis Philbin, James Taylor
- Season 16 Alec Baldwin, Paul Mooney, Ryan Adams
- Season 16 Ashley Olsen, Paul Rudd, John Legend
- Season 16 Marcia Cross, Alan Zweibel
- Season 16 Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais
- Season 16 Tom Brokaw, Vera Farmiga
- Season 16 Ben Stiller, Q-Tip
- Season 16 Natalie Portman, Artie Lange, Brad Paisley
- Season 16 Ted Turner, Jamie Oliver, Taylor Swift
- Season 16 Don Rickles, Amy Brenneman, Alicia Keys
- Season 16 Russell Brand, Charlie Haden
- Season 16 Bruce Willis, Sia
- Season 16 Bill Cosby, Matt Braunger
- Season 16 Emma Thompson, Michelle Felicetta, Purple Reign
- Season 16 Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash
- Season 16 Katie Couric, Dev Patel, Mr. Brownstone
- Season 16 Stephen Colbert, Kristen Stewart, Super Diamond
- Season 16 James Franco, Bruce McCall, The Allstarz
- Season 16 Nicole Kidman, Simon Baker, Kanye West
- Season 16 Reese Witherspoon, Harry Connick Jr.
- Season 16 Teri Hatcher, Ludacris
- Season 16 Denis Leary, John Mayer
- Season 16 Tom Arnold, Faith Hill
- Season 16 Jennifer Connelly, Anderson Cooper, The Duke Spirit
- Season 16 Amy Adams, Michael Sheen, Jamey Johnson
- Season 16 Keanu Reeves, Paula Abdul, Loudon Wainwright III
- Season 16 Sen. John McCain, Bon Iver
- Season 16 Meryl Streep, Jeff Altman
- Season 16 Adam Sandler
- Season 16 Tom Cruise, Fall Out Boy
- Season 16 Jennifer Aniston, Broken Social Scene
- Season 16 Will Smith, Of Montreal
- Season 16 Jerry Seinfeld, Leona Lewis
- Season 16 Dustin Hoffman, Todd Rundgren
- Season 16 Jay Thomas, Mickey Rourke, Darlene Love
- Season 16 Tracy Morgan, Matt Braunger
- Season 16 Kate Hudson, Glasvegas
- Season 16 Kevin James, Becky Quick, Erin McCarley
- Season 16 Ricky Gervais, Rose Byrne, Okkervil River
- Season 16 Kate Winslet, Marv Albert
- Season 16 Kiefer Sutherland, Wendy Liebman
- Season 16 Billy Crystal, Kara DioGuardi
- Season 16 Salma Hayek, Jimmie Walker
- Season 16 Clint Eastwood, Randy Rogers Band
- Season 16 Kyra Sedgwick, Gwen Ifill
- Season 16 Zach Braff, Arj Barker, The Airborne Toxic Event
- Season 16 Brian Williams, Ben Kweller
- Season 16 Evangeline Lilly, Seth Meyers, Andrew Bird
- Season 16 Lauren Graham, Guy Fieri, MENEW
- Season 16 Renee Zellweger, Tony Dungy, Graham Nash sits in with the band
- Season 16 Mary Hicks, the Gaslight Anthem
- Season 16 Ben Roethlisberger, Steve Martin
- Season 16 Rod Blagojevich, Richard Jenkins
- Season 16 Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt
- Season 16 Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne
- Season 16 Dakota Fanning, Keith Alberstadt, Beirut
- Season 16 Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal
- Season 16 The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards
- Season 16 Joaquin Phoenix, Bar Refaeli, Anthony Hamilton
- Season 16 Chris Russo, the Jonas Brothers, Ashford & Simpson
- Season 16 Martha Stewart, Jake Johannsen, Matt Nathanson
- Season 16 Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel
- Season 16 Bonnie Hunt, M. Ward
- Season 16 Donald Trump, Antony and the Johnsons
- Season 16 David Spade, Jeffrey Sachs, David Sanborn with Sam Moore
- Season 16 Barbara Walters, Mike Birbiglia, Shemekia Copeland
- Season 16 Katie Couric, U2
- Season 16 Felicity Huffman, Artie Lange, U2
- Season 16 Dr. Phil McGraw, U2
- Season 16 Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic
- Season 16 Jason Segel, Brian Kiley, U2
- Season 16 Russell Brand, Jack Hanna
- Season 16 Stupid Pet Tricks, Paul Rudd, Razorlight
- Season 16 Tom Brokaw, An Horse
- Season 16 Andy Samberg, Paul Teutul Sr., the Broadway cast of "West Side Story"
- Season 16 Will Ferrell, Cursive
- Season 16 Nicolas Cage, Rachel Maddow
- Season 16 Julia Roberts, Bell X1
- Season 16 Craig Ferguson, Ginnifer Goodwin, Modest Mouse
- Season 16 Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson
- Season 16 David Spade, Richard Zoglin, David Sanborn and Sam Moore
- Season 16 Hugh Laurie, Bloc Party
- Season 16 Mary Tyler Moore, Blake Lively, White Lies
- Season 16 Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones
- Season 16 Seth Rogen, Tom Dreesen, Adele
- Season 16 Bill O'Reilly, Marianne Faithfull
- Season 16 Marg Helgenberger, Francisco Palacios, Ray LaMontagne
- Season 16 Michael J. Fox, the Fray
- Season 16 Denis Leary, Diana Krall
- Season 16 Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins
- Season 16 Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs
- Season 16 Drew Barrymore, Jack McBrayer, Neko Case
- Season 16 Matthew Perry, Elisha Cuthbert, Rascal Flatts
- Season 16 Russell Crowe, Joe Wong
- Season 16 Jeff Goldblum, Jeff Dunham
- Season 16 Nathan Lane, Tinted Windows
- Season 16 Beyonce, Jim Parsons
- Season 16 Jamie Foxx, Lauren Conrad, the Dead
- Season 16 Michael Keaton, Lily Allen
- Season 16 Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford
- Season 16 Dolly Parton, Zachary Quinto
- Season 16 Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra
- Season 16 Regis Philbin, a performance by the Broadway cast of "Hair"
- Season 16 Kiefer Sutherland, Jim Norton, Bat for Lashes
- Season 16 Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West
- Season 16 Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand
- Season 16 Bruce Willis, Ben Harper & Relentless7
- Season 16 Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective
- Season 16 Matthew Broderick, Brian Regan, Chris Cornell
- Season 16 Tom Hanks, the Killers
- Season 16 Alec Baldwin, Maya Rudolph, Chrisette Michele
- Season 16 Robin Williams, Wynton Marsalis
- Season 16 Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard
- Season 16 John Goodman, Tommy Tiernan, Mastodon
- Season 16 Ben Stiller, White Rabbits
- Season 16 Jane Fonda, Piedmont Bird Callers, Kenny Chesney
- Season 16 Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear
- Season 16 Amy Sedaris, Ed Helms, Jean Redpath
- Season 16 Ricky Gervais, Green Day
- Season 16 Bill Cosby, Helio Castroneves, Melody Gardot
- Season 16 Jack Hanna, John Krasinski
- Season 16 Jessica Biel, Zach Galifianakis, Steve Earle
- Season 16 Elvis Costello, a Top Ten List presented by Neil Patrick Harris
- Season 16 Paris Hilton, Calvin Borel, Steven Wright
- Season 16 Howard Stern, Mos Def
- Season 16 Julia Roberts, Black Eyed Peas
- Season 16 Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns' Steve Nash
- Season 16 Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin
- Season 16 Sandra Bullock, Pete Correale, P.J. Harvey & John Parish
- Season 16 Jack Black, M.A. Sanjayan
- Season 16 Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band
- Season 16 Ryan Reynolds, Padma Lakshmi, the Eels
- Season 16 Danny DeVito, Bear Grylls, Phoenix
- Season 16 Jada Pinkett Smith, Michael Cera, the Sounds
- Season 16 Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority
- Season 16 Sandra Day O'Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover
- Season 16 Ray Romano, St. Vincent
- Season 16 Johnny Depp, Megan Fox
- Season 16 Martin Short, Regina Spektor
- Season 16 Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band
- Season 16 Sacha Baron Cohen, Joel McHale
- Season 16 Queen Latifah, Emma Watson
- Season 16 Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno
- Season 16 Rainn Wilson, Larry Miller, Maxwell
- Season 16 Jonah Hill, Gar Ryness, Kelly Clarkson
- Season 16 Edie Falco, Michael Showalter, Wilco with Feist
- Season 16 Paul McCartney, a Top Ten List presented by Bruce Willis
- Season 16 Anderson Cooper, Anna Paquin, Grizzly Bear
- Season 16 Tom Arnold, Metric, a Top Ten List presented by Dave's mom Dorothy
- Season 16 Katherine Heigl, Jeff Altman, Spinnerette
- Season 16 Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink
- Season 16 Tracy Morgan, Leslie Mann, Diane Birch
- Season 16 Sean "Diddy" Combs, Vera Farmiga, Ginuwine with Missy Elliott
- Season 16 Amy Poehler, Nick Griffin, Judy Collins
- Season 16 Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle
- Season 16 Katie Couric, Silversun Pickups
- Season 16 Amy Adams, Tom Dreesen, Elbow
- Season 16 Adam Sandler, Cage the Elephant
- Season 16 Regis Philbin, Ted Alexandro, Dave Matthews Band
- Season 16 Quentin Tarantino, Eric Ripert, Robert Cray
- Season 16 Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears
- Season 16 Mike Myers, Ken Burns
- Season 16 Anna Wintour, Mark Teixeira
- Season 16 Renee Zellweger, Gary Mule Deer
- Season 16 Christina Applegate, Brendan Benson, Patton Oswalt
- Season 16 Anna Wintour, Mark Teixeira
- Season 16 Mary-Louise Parker, Eugene Levy, Jet
- Season 16 Anne Heche, Jim Parsons, Care Bears on Fire
- Season 16 Andy Roddick, Rachael Ray, Mutemath
- Season 16 Artie Lange, Todd Barry, Imogen Heap
Late Show with David Letterman - Season 16 Episode 163 Danny DeVito, Bear Grylls, Phoenix
6.30 63 minutes Dave welcomes the star of the FX network comedy, "It's Always Sunny in Philadelphia", Danny Devito. Topics include Danny's now infamous Youtube moment when it appeared he was drunk on the set. He claims he wasn't.
Later, star of the Discovery Channel/Science Channel series, "Man vs. Wild", Bear Grylis stops by to discuss his series upcoming episode with superstar Will Farrell.
Phoenix is the Musical Guest.
