Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 10 Amanda Peet, Tom Dreesen
- Season 10 Jeff Goldblum, George Miller
- Season 10 Drea de Matteo, Sarah Vowell, The Doves
- Season 10 Peter Jennings, John Witherspoon
- Season 10 John McEnroe, Piper Perabo, Queens of the Stone Age
- Season 10 Jennifer Esposito, Marianne Faithful
- Season 10 Bill Clinton, Nanci Griffith
- Season 10 Regis Philbin, Linda Thompson
- Season 10 Megan Mullally, Rich Hall
- Season 10 Bruce Willis, Eve
- Season 10 Jack Hanna, Tom Cavanagh, Civil War Reenactment
- Season 10 Reese Witherspoon, Juan Montoya, India.Arie
- Season 10 Rose McGowan, Phillipe Petit
- Season 10 Lauren Graham, Colin Quinn
- Season 10 Patricia Heaton, Murray Walker
- Season 10 David Schwimmer, Avril Lavigne
- Season 10 Anthony LaPaglia, Effie Nielson, Clinic
- Season 10 Edward Norton, John Mayer
- Season 10 David Arquette, Todd Lynn
- Season 10 Jennifer Love Hewitt, Tom Petty and The Heartbreakers
- Season 10 John McCain, David Sedaris
- Season 10 Charles Barkley, Franco Zeffirelli, Nitty Gritty Dirt Band
- Season 10 Michelle Pfeiffer, Bon Jovi
- Season 10 Johnny Knoxville, Ron White
- Season 10 Debra Messing, Pink
- Season 10 Thandie Newton, Faith Hill
- Season 10 Rudolph Giuliani, Naomi Watts
- Season 10 Samuel L. Jackson, Santana & Michelle Branch
- Season 10 P. Diddy, Eddie Brill
- Season 10 Bonnie Hunt, Christina Aquilera
- Season 10 Salma Hayek, Tori Amos
- Season 10 Warren Zevon
- Season 10 Jerry Seinfeld, Foo Fighters
- Season 10 Don Rickles, Jim Gaffigan
- Season 10 Stupid Human Tricks, Sean Hayes, Willie Nelson & Ryan Adams
- Season 10 Julianne Moore, Grant Paulsen, Blind Boys of Alabama
- Season 10 Kid Inventors, Tom Brokaw, The Wallflowers
- Season 10 Brittany Murphy, Al Lubel
- Season 10 Robin Williams, Emily Proctor
- Season 10 Kelly Ripa, Emmitt Smith, Missy Elliott
- Season 10 Barbara Walters, Joe Pantoliano
- Season 10 Maggie Gyllenhaal, Pearl Jam
- Season 10 Al Gore, Pearl Jam
- Season 10 Kevin James, matchbox 20
- Season 10 Shania Twain, Cristiano da Matta
- Season 10 Adam Sandler, Pussycat Dolls
- Season 10 Ice Cube, Cast of Hairspray
- Season 10 Harry Connick Jr., Larry Miller
- Season 10 Stupid Pet Tricks, Lisa Kudrow, Audioslave
- Season 10 George Clooney, Jack Hanna
- Season 10 Ray Romano, Jurassic 5
- Season 10 Amy Sedaris, The Strokes
- Season 10 Liza Minnelli, Jann Karam
- Season 10 Jennifer Lopez, Sum 41
- Season 10 Jason Alexander, Ryan Adams
- Season 10 Nia Vardalos, Barry Sonnenfeld
- Season 10 Allison Janney, Martin Scorsese
- Season 10 Natasha Richardson, Mike Birbiglia, David Gray
- Season 10 Catherine Zeta-Jones, Coldplay
- Season 10 Drew Barrymore, Rod Stewart
- Season 10 Denzel Washington, Daniel Bouloud
- Season 10 Tom Hanks, Phish
- Season 10 Liv Tyler, Jay Thomas, Darlene Love
- Season 10 Ashton Kutcher, Jason Kidd
- Season 10 Isabella Rossellini, Mort Sahl
- Season 10 Michael Caine, George Foreman
- Season 10 Richard Gere, Chris Elliott
- Season 10 Merv Griffin, Interpol
- Season 10 Renee Zellweger, Chuck Barris
- Season 10 Andy Richter, Rich Hall
- Season 10 Jimmy Kimmel, Simon Baker
- Season 10 Claire Danes, Bob Sarlatte
- Season 10 Sandra Bullock, Marv Albert
- Season 10 George Clooney, Soundtrack of Our Lives
- Season 10 Joan Rivers, Kathleen Edwards
- Season 10 Simon Cowell, Topher Grace, Vienna Teng
- Season 10 Regis Philbin, John C. Reilly
- Season 10 Tina Fey, Jonathan Ames, Johnny Marr & The Healers
- Season 10 Ellen DeGeneres, Zwan
- Season 10 Bonnie Hunt, John Witherspoon
- Season 10 Show #1944Kate Hudson, Jack Hanna
- Season 10 Matthew McConaughey, John Gruden, The Roots
- Season 10 Kelsey Grammer, Michael Tong, B.B. King and Shemeika Copeland
- Season 10 Stupid Pet Tricks, Tom Brokaw, The Pretenders
- Season 10 Brendan Fraser, Kids in The Hall, Bonnie Raitt, Keb' Mo, Kim Wilson
- Season 10 Matthew Broderick, Tony Bennett & k.d. Lang
- Season 10 Amy Brennamen, Nate Erwin, Vince Gill
- Season 10 Queen Latifah, Colin Quinn, Lou Reed
- Season 10 Kid Scientists, Kurt Russell
- Season 10 Kate Winslet, Dennis Regan, Rufus Wainwright
- Season 10 Dr. Phil, Beck
- Season 10 Vince Vaughn, Sarah Vowel, Beck
- Season 10 Kevin Spacey, Reggie Miller
- Season 10 Champion Turkey Callers, Marg Helgenberger, The Flaming Lips
- Season 10 Jeff Daniels, Lynne Cox, Steven Wright
- Season 10 Steve Martin, Foo Fighters
- Season 10 Stupid Human Tricks, Sharon Osborne, Norah Jones
- Season 10 Bruce Willis, Dan Rather, Carmen Electra, Brian Kiley
- Season 10 John McEnroe, Tom Arnold, Eric Ripert, Todd Barry, Jason Mras
- Season 10 Regis Philbin, Charles Grodin, Susan Lucci, Greg Giraldo, Kathleen Edwards
- Season 10 Whoopi Goldberg, Jessica Lange, Dave Chappelle, Andy Vistola, Ben Harper
- Season 10 Vince Vaughn, Rosie Perez, Geri Halliwell, Dwayne Kennedy, Paul Simon
- Season 10 Elvis Costello, Kim Cattrell, Eddie Izzard, Mitch Hedberg
- Season 10 Will Ferrell, Chris Rock, Crispin Glover, Jake Johannsen, American Hi-Fi
- Season 10 Megan Mullally, Molly Shannon, Isaac Mizrahi, Bonnie McFarlane
- Season 10 Brad Garrett, Cuba Gooding Jr., Julie Bowen, Reggie McFadden, Lyle Lovett
- Season 10 Tom Dreesen, Kiefer Sutherland, Frank Gershin, Suzanne Westenhoefer, The Music
- Season 10 Bonnie Hunt, Carson Daley, Eddie Griffin, Ron Beth-Israel, Fabolous
- Season 10 Paul Schaffer, Bob Dole, Connie Nielsen, Jeff Foxworthy, Cat Power
- Season 10 Bill Cosby, Andrew Firestone, Clark Tery, Sofia Vergara, The DA
- Season 10 Luke Wilson, Kelly Preston, Taye Diggs, Hilary Burton, Seether
- Season 10 Billy Crystal, Michael Barimo
- Season 10 Colin Farrell, Rosanne Cash
- Season 10 Helen Hunt, Jeremy Suarez, Cory Branan
- Season 10 High-Jumping Dogs, Vin Diesel, Bo Diddley
- Season 10 Hilary Swank, Jimmie Walker
- Season 10 Adam Sandler, The Folksmen
- Season 10 Lisa Marie Presley, Jamie Kennedy
- Season 10 Jane Krakowski, Jim Boeheim, Pete Yorn
- Season 10 Tom Brokaw, Tom Russell & Nanci Griffith
- Season 10 Michael Douglas, Todd Rundgren
- Season 10 Anthony LaPaglia, Brian Regan, The Exies
- Season 10 Ashton Kutcher, Jack Hanna
- Season 10 Ellen DeGeneres, John Malkovich
- Season 10 Charlize Theron, Sue Johanson, Minus 5 with Wilco
- Season 10 Bernie Mac, Amanda Peet
- Season 10 Halle Berry, Don Rickles
- Season 10 Kelly Rippa, Good Charlotte
- Season 10 Stupid Human Tricks, Hugh Jackson, Kelly Clarkson
- Season 10 David Hyde Pierce, Rube Goldberg Contest Winners, Ziggy Marley
- Season 10 Megan Mullally, Marilyn Manson
- Season 10 Albert Brooks, Jeffery Ross, The Libertines
- Season 10 Stupid Pet Tricks, Kevin James, Jenna Morasca
- Season 10 David Williams & Ronald Young, Jada Pinkett Smith, The Jayhawks
- Season 10 Sean Hayes, Eric Ripert, Avril Lavigne
- Season 10 Rene Zellweger, Jack Johnson
- Season 10 John Goodman, D.H. Hughley, NAS with Alicia Keys
- Season 10 Mark Wahlberg, Jesse James, the Sounds
- Season 10 Jim Carrey, Chevelle
- Season 10 Regis Philbin, 3 Doors Down
- Season 10 Antonio Banderas, Heidi Klum, Liam Lynch
- Season 10 Peter Krause, Jim Gaffigan, Widespread Panic
- Season 10 Adrien Brody, Gil de Ferran, John Mellencamp
- Season 10 Alec Baldwin, Tom Dreesen
- Season 10 Seth Green, Amy Sedaris, Lucinda Williams
- Season 10 Barbara Walters, Tanya Streeter
- Season 10 Tom Arnold, Darrell Hammond, Karolina Kurkova, Eddie Brill, Train
- Season 10 Juliette Binoche, Joe Queenan, Blur
- Season 10 Bruce Willis, Chris Moneymaker
- Season 10 Lauren Graham, Marv Albert, Bright Eyes
- Season 10 Harrison Ford, Annie Lennox
- Season 10 Tom Green, Jolene Blalock, Scott Stevens, Isaac Britty, Damien Rice
- Season 10 Hilary Clinton, Emmylou Harris
- Season 10 Rob Reiner, Paul Teutul Sr. & Jr., The New Pornographers
- Season 10 Johnny Depp, Christine Todd Whitman, B.B. King
- Season 10 Sarah Jessica Parker, The Dead
- Season 10 Kelsey Grammer, Treat Williams, James Earl Jones, Jamie Lynn-Sigler, Kathleen Madigan, Jesse Malin
- Season 10 Demi Moore, Verbana
- Season 10 Drew Barrymore, Simon Cowell
- Season 10 Lucy Liu, Avigayil Wardein, Nick Cave and The Bad Seeds
- Season 10 Piedmont Bird Callers, Luke Wilson, The Yeah Yeah Yeahs
- Season 10 Jimmy Fallon, Kristanna Loken, Dax, Chloe Sevigny, Bill Scheft, Rufus Wainwright
- Season 10 Lisa Marie Presley, Ryan Pinkston
- Season 10 Allison Janney, Nigella Lawson, Howard Tate
- Season 10 Barry Zito, Mandy Moore, Grandaddy
- Season 10 Ari Fleischer, Beyonce Knowles
- Season 10 Jeff Bridges, Alan Harvey, Joseph Arthur
- Season 10 Aron Ralston, Tobey Maguire
- Season 10 National Hollerin' Champions, Kristin Davis, Jane's Addiction
- Season 10 Joaquin Phoenix, Blues Traveler
- Season 10 Sylvester Stallone, Ben Curtis
- Season 10 Denis Leary, Queens of the Stone Age
- Season 10 Jesse Grabow, Jason Biggs, Robert C. Nichol
- Season 10 Eugene Levy, Eels
- Season 10 Seann William Scott, Jonathan Ames, Fountains of Wayne
- Season 10 Melanie Griffith, Pamela Reed
- Season 10 Naomi Watts, Jeff Stilson, O.A.R.
- Season 10 Kate Hudson, Cast of Camp
- Season 10 Colin Farrell, Robert Randolph & The Family Band
- Season 10 Samuel L. Jackson, Rick Reilly, Pharrell with Clipse
- Season 10 Brittany Murphy, Carey Hart, Dashboard Confessional
- Season 10 David Duchovny, Brett Butler, The New Amsterdams
- Season 10 Chris Rock, The Star Spangles
- Season 10 Bill Murray, Pete Sampras
- Season 10 David Spade, Bob Sarlatte, Maroon 5
- Season 10 Tony Hawk, John McEnroe, Rooney
- Season 10 Bonnie Hunt, Don Gavin
Late Show with David Letterman - Season 10 Episode 72 Claire Danes, Bob Sarlatte
6.30 63 minutes Dave announces that today is the 3rd anniversary of his quintuple bypass, and upon mentioning this, Regis interrupts the jokes to give Dave a quick check-up. ""You're screwed,"" Regis proclaims. Throughout the night, Dave reflects on the bypass, claiming he ran five miles six weeks after the bypass. Near the end of the show, Dave tells former announcer Bob Sarlette that his cholesterol is a healthy 46.
